Per-Olof Hasselgren • Research Publications

2010s
  • Smith I, Alamdari N, O’Neal P, Gonnella P, Aversa Z, Hasselgren PO.  Sepsis increases the expression and activity of the transcription factor Forkhead Box O 1 (FOXO1) in skeletal muscle by a glucocorticoid-dependent mechanism.  Int J Biochem Cell Biol 2010; 42:701-711.
  • Itagaki K, Menconi M, Antoniu B, Zhang Q, Gonnella P, Soybel D, Hauser C, Hasselgren PO.  Dexamethasone stimulates store-operated calcium entry and protein degradation in cultured L6 myotubes through a phospholipase A2-dependent mechanism.  Am J Physiol Cell Physiol 2010; 298:C1127-C1139.
  • Alamdari N, Smith IJ, Aversa Z, Hasselgren PO.  Sepsis and glucocorticoids upregulate p300 and downregulate HDAC6 expression and activity in skeletal muscle.  Am J Physiol Regulatory Integrative and Comparative Physiology 2010; 299: R509-R520.
  • Menconi MJ, Arany ZP, Alamdari N, Aversa Z, Gonnella P, O’Neal P, Smith I, Tizio S, Hasselgren PO.  Sepsis and glucocorticoids downregulate the expression of the nuclear cofactor PGC-1beta in skeletal muscle.  Am J Physiol Endocrinol Metab 2010; 299: E533-E543.
  • Smith IJ, Aversa Z, Alamdari N, Petkova V, Hasselgren PO.  Sepsis downregulates myostatin mRNA levels without altering myostatin protein levels in skeletal muscle.  J Cell Biochem 2010; 111: 1059-1073.
  • Hasselgren PO, Alamdari N, Aversa Z, Gonnella P, Smith IJ, Tizio S.  Corticosteroids and muscle wasting – role of transcription factors, nuclear cofactors, and hyperacetylation.  Curr Opin Clin Nutr Metabol Care 2010; 13:423-428.
  • Smith IJ, Aversa Z, Hasselgren PO, Pacelli F, Rosa F, Doglietto GB, Bossola M. Calpain activity is increased in skeletal muscle from gastric patients with no or only minimal weight loss. Muscle and Nerve 2011; 43: 410-414.
  • O’Neal P, Mowschenson P, Connolly J, Hasselgren PO. Large parathyroid tumors have an increased risk for atypia and carcinoma. Am J Surg 2011; 202: 146-150.
  • Gonnella P, Alamdari N, Tizio S, Aversa Z, Petkova V, Hasselgren PO. C/EBPβ regulates dexamethasone-induced muscle cell atrophy and expression of atrogin-1 and MuRF1. J Cell Biochem 2011; 112: 1737-1748.
  • Aversa Z, Alamdari N, Hasselgren PO. Molecules modulating gene transcription during muscle wasting in cancer, sepsis and other critical illness. Crit Rev Clin Lab Sci 2011; 48: 71-86.
  • Hasselgren PO. Muscle wasting. In JL Vincent and JB Hall (eds), Encyclopedia of Intensive Care Medicine, 2011: DOI 10.1007/978-3-642-00418-6_663.
  • Goldfarb M, O’Neal P, Osborn C, Hasselgren PO, Schwaitzberg S. Endocrine. In Goldberg M, Gromski MA, Hurst JM, Jones DB (eds), Pocket Surgery – The Beth Israel Deaconess Medical Center Handbook of Surgery. Wolters Kluwer/Lippincott Williams & Wilkins, 2011, 16/1-16/16.
  • Chamberlain W, Gonnella P, Alamdari N, Aversa Z, Hasselgren PO. Multiple muscle wasting-related transcription factors are acetylated in dexamethasone-treated muscle cells. Biochem Cell Biol 2012; 90: 200-208.
  • Alamdari N, Aversa Z, Castillero E, Gurav A, Petkova V, Tizio S, Hasselgren PO. Resveratrol prevents dexamethasone-induced expression of the muscle atrophy-related ubiquitin ligases atrogin-1 and MuRF1 in cultured myotubes through a SIRT1-dependent mechanism. Biochem Biophys Res Commun 2012; 417: 528-533.
  • Aversa Z, Alamdari N, Castillero E, Muscaritoli M, Rossi Fanelli F, Hasselgren PO. β-hydroxy-β-methylbutyrate (HMB) prevents dexamethasone-induced myotube atrophy. Biocehm Biophys Res Commun 2012; 423: 739-743.
  • Alamdari N, Toraldo G, Aversa Z, Smith I, Castillero E, Renaud G, Qaisar R, Larsson L, Jasuja R, Hasselgren PO. Loss of muscle strength during sepsis is in part regulated by glucocorticoids and is associated with reduced muscle fiber stiffness. Am J Physiol Regul Integr Comp Physiol 2012; 303: R1090-R1099.
  • Alamdari N, Hasselgren PO. Letter to the Editor. J Cachexia Sarcopenia Muscle 2012; 3: 71-72.
  • Hasselgren PO, Cannon JW, Fischer JE. Perioperative management: Practical principles, molecular basis of risk, and future directions. In Fischer JE (ed). Mastery of Surgery, 6th edition, 2012; 25-56.
  • Castillero E, Alamdari N, Aversa Z, Gurav A, Hasselgren PO. PPARβ/δ regulates glucocorticoid- and sepsis-induced FOXO1 activation and muscle wasting. PLoS ONE 2013; 8 (3): e59726.
  • Cypess A, White AP, Vernochet C, Schulz TJ, Xue R, Sass CA, Roberts-Toler C, Weiner LS, Sze C, Chako AT, Deschamps LN, Herder L, Truchan N, Glasgow A, Holman AR, Gavrila A, Hasselgren PO, Mori MA, Molla M, Tseng YH. Anatomical localization and bioenergetic potential of human brown adipose tissue. Nature Medicine 2013; 19: 635-639.
  • Aversa Z, Alamdari N, Castillero E, Muscaritoli M, Rossi Fanelli F, Hasselgren PO. CaMKII activity is reduced in skeletal muscle during sepsis. J Cell Biochem 2013; 114: 1294-1305.
  • Castillero E, Alamdari N, Lecker SH, Hasselgren PO. Suppression of atrogin-1 and MuRF1 prevents dexamethasone-induced atrophy of cultured myotubes. Metabolism 2013; 62: 1495-1502.
  • Alamdari N, Aversa Z, Castillero E, Hasselgren PO. Acetylation and deacetylation – novel factors in muscle wasting. Metabolism 2013; 62:1-11.
  • Hasselgren PO. β-hydroxy-β-methylbutyrate (HMB) and prevention of muscle wasting. Editorial. Metabolism 2014; 63:5-8.
  • Moon HS, Dincer F, Huh JY, Hasselgren PO, Schneider BE, Mantzoros CS. Identification, and saturable nature, of signaling pathways induced by metreleptin in humans: comparative evaluation of in vivo, ex vivo and in vitro administration. Diabetes 2015; in press.
  • Mele A, Hasselgren PO. Adrenalectomy. For Minimally Invasive Surgery: Laparoscopy, Therpeutic Endoscopy, and NOTES. Jones D et al (eds). 2015; in press.
2000s
  • Parikh, AA, Moon MR, Pritts TA, Fischer JE, Szabo C, Hasselgren PO, Salzman AL. IL-1β induction of NF-κB activation in human intestinal epithelial cells is independent of oxyradical signaling. Shock 2000; 13:8-13.
  • Fischer DR, Sun X, Gang G, Pritts T, Hasselgren PO. The gene expression of ubiquitin ligase E3alpha is upregulated in skeletal muscle during sepsis in rats – potential role of glucocorticoids. Biochem Biophys Res Commun 2000; 267:504-508.
  • Pritts TA, Wang Q, Sun X, Moon MR, Fischer DR, Fischer JE, Wong HR, Hasselgren PO. Induction of the stress response in vivo decreases NF-κB activity in jejunal mucosa of endotoxemic mice. Arch Surg 2000; 135:860-866.
  • Luo GJ, Sun X, Hasselgren PO. Hyperthermia stimulates energy-proteasome-dependent degradation of short- and long-lived proteins in cultured myotubes. Am J Physiol 2000; 278:R749-R756.
  • Moon, MR, Parikh AA, Pritts TA, Kane C, Fischer JE, Salzman AL, Hasselgren PO. IL-1β induces complement component C3 and IL-6 production at the basolateral and apical membranes of human intestinal epithelial cells. Shock 2000; 13:374-378.
  • Pritts TA, Moon MR, Wang Q, Salzman AL, Fischer JE, Hasselgren PO. Activation of NF-κB varies in different regions of the gastrointestinal tract during endotoxemia. Shock 2000; 14:118-122.
  • Li B, Fang CH, Hasselgren PO. Degradation of methoxysuccinyl-phe-leu-phe-7-amido-4-trifluoromethyl coumarin (FLF) in cultured myotubes and HepG2 cells is proteasome – and calpain/calcium-dependent. Int J Biochem Cell Biol 2000; 32:677-686.
  • Fischer D, Gang G, Pritts T, Hasselgren PO. Sepsis-induced muscle proteolysis is prevented by a proteasome inhibitor in vivo. Biochem Biophys Res Commun 2000; 270:215-221.
  • Hungness ES, Safa M, Shaughnessy EA, Aron B, Gazder PA, Hawkins H, Lower E, Yassin R, Seeskin C, Hasselgren PO. Bilateral synchronous breast cancer: Mode of detection and comparison of histology between the two breasts. Surgery 2000; 128:702-707.
  • Fang CH, Li BG, Sun X, Hasselgren PO. Insulin-like growth factor I reduces ubiquitin and ubiquitin-conjugating enzyme gene expression but does not inhibit muscle proteolysis in septic rats. Endocrinology 2000; 141:2743-2751.
  • Fang CH, Li BG, Fischer DR, Wang JJ, Runnels HA, Monaco JJ, Hasselgren PO. Burn injury upregulates the activity and gene expression of the 20S proteasome in rat skeletal muscle. Clin Sci 2000; 99:181-187.
  • Hungness ES, Pritts TA, Luo G, Hasselgren PO. IL-1β activates C/EBP-β and C/EBP-δ in human enterocytes through a mitogen activated protein kinase (MAPK) signaling pathway. Surg Forum 2000; 51:207-209.
  • Gang GI, Penner CG, Fischer DR, Hasselgren PO. Sepsis upregulates the DNA binding activity of the inflammatory transcription factors NF-κB, C/EBP, and AP-1 in rat skeletal muscle. Surg Forum 2000; 51:214-216.
  • Pritts TA, Hungness ES, Luo GJ, Parikh AA, Moon MR, Hasselgren PO. Proteasome inhibitors block NF-κB activation but induce IL-6 production in human enterocytes. Surg Forum 2000; 51:166-169.
  • Fang CH, Sun X, Li BG, Fischer DR, Pritts TA, Penner CG, Hasselgren PO. Burn injury in rats upregulates the gene expression of the ubiquitin-conjugating enzyme E214k in skeletal muscle. J Burn Care Rehab 2000; 21:528-534.
  • Hungness ES, Pritts TA, Luo GJ, Sun X, Penner G, Hasselgren PO. The transcription factor AP-1 is activated and IL-6 production is increased in IL-1β-stimulated human enterocytes. Shock 2000; 14:386-391.
  • Wang Q, Sun X, Pritts TA, Wong HR, Hasselgren PO. Induction of the stress response increases IL-6 production in intestinal mucosa of endotoxemic mice. Clin Sci 2000; 99:489-496.
  • Hasselgren PO. Catabolic response to stress and injury – implications for regulation. World J Surg 2000; 24:1452-1459.
  • Hasselgren PO. Protein metabolism in surgery. In: Norton JA, Bollinger RR, Chang AE, Lowry SF, Mulvihill SJ, Pass HI, Thompson RW, eds. Surgery: Basic Science and Clinical Evidence. New York: Springer-Verlag, 2000:105-121.
  • Pritts TA, Fischer DR, Hasselgren PO. Metabolic depletion and failure – muscle cachexia in injury and sepsis. In: Baue AE, Faist E, Fry D, eds. Multiple Organ Failure. New York: Springer-Verlag, 2000:378-388.
  • Fischer DR, Sun X, Williams AB, Gang G, Pritts TA, James JH, Molloy M, Fischer JE, Paul RJ, Hasselgren PO. Dantrolene reduces serum TNFα and corticosterone levels and muscle calcium, calpain gene expression, and protein breakdown in septic rats. Shock 2001; 15:200-207.
  • Penner CG, Gang G, Wray C, Fischer JE, Hasselgren PO. The transcription factors NF-κB and AP-1 are differentially regulated in skeletal muscle during sepsis. Biochem Biophys Res Commun 2001; 281:1331-1336.
  • O’Brien DP, Nelson LA, Stern LE, Williams JL, Kemp CJ, Wang Q, Tso P, Erwin CR, Hasselgren PO, Warner BW. Epithelial permeability is not increased in rats following small bowel resection. J Surg Res 2001; 97:65-70.
  • Wang Q, Fang CH, Hasselgren PO. Intestinal permeability is reduced and IL-10 levels are increased in septic IL-6 knock-out mice. Am J Physiol 2001; 281:R1013-R1023.
  • Hungness ES, Luo G, Robb BW, Hershko DD, Hasselgren PO. Heat shock activates C/EBP-β and augments IL-6 production in IL-1 β-treated human enterocytes. Surg Forum 2001; 52:135-137.
  • Hershko DD, Robb BW, Hungness ES, Hasselgren PO. Arsenite inhibits interleukin-6 production in human enterocytes by altering transcriptional regulation of the IL-6 gene. Surg Forum 2001; 52:137-140.
  • Wray CJ, Luo G, Hungness ES, Hasselgren PO. Genomic analysis of glucocorticoid-induced muscle cachexia. Surg Forum 2001; 52:142-144.
  • Luo GJ, Sun X, Hungness E, Hasselgren PO. Heat shock protects L6 myotubes from catabolic effects of dexamethasone and prevents downregulation of NF-κB. Am J Physiol 2001; 281:R1193-R1200.
  • Hasselgren PO, Fischer JE. Muscle cachexia: current concepts of intracellular mechanisms and molecular regulation. Ann Surg 2001; 233:9-17.
  • Hasselgren PO, Fischer DR, Pritts T. Models of protein metabolism. In: Souba WW, Wilmore DW, eds. Surgical Research. San Diego: Academic Press, 2001:825-844.
  • Hasselgren PO, Fischer DR, Pritts T. Metabolic response to trauma and infection. In: Baker RJ, Fischer JE, eds. Mastery of Surgery, 4th Edition. Philadelphia: Lippincott, Williams & Wilkins, 2001:3-22.
  • Penner G, Gang G, Sun X, Wray C, Hasselgren PO. C/EBP DNA binding activity is upregulated by a glucocorticoid-dependent mechanism in septic muscle. Am J Physiol 2002; 282:R439-R444.
  • Hungness ES, Pritts TA, Luo GJ, Hershko DD, Robb BW, Hasselgren PO. IL-1β activates C/EBP-β and C/EBP-δ in human enterocytes through a mitogen-activated protein-kinase signaling pathway. Int J Biochem Cell Biol 2002;34:382-395.
  • Hasselgren PO, Wray C, Mammen J. Molecular regulation of muscle cachexia – it may be more than the proteasome. Biochem Biophys Res Commun 2002; 290:1-10.
  • Sun X, Fischer DR, Pritts TA, Wray CJ, Hasselgren PO. Expression and binding activity of the glucocorticoid receptor are upregulated in septic muscle. Am J Physiol 2002; 282:R509-R518.
  • Hershko D, Robb BW, Hungness ES, Luo G, Hasselgren PO. Arsenite stabilizes IκBα and prevents NF-κB activation in IL-1β-stimulated Caco-2 cells independent of the heat shock response. J Cell Biochem 2002; 84:687-698.
  • Wang Q, Hasselgren PO. Heat shock response reduces intestinal permeability in septic mice: Potential role of IL-10. Am J Physiol 2002;282:R669-R676.
  • Hungness ES, Robb BW, Luo GJ, Pritts TA, Hershko DD, Hasselgren PO. Proteasome inhibitors activate the transcription factors C/EBP-β and C/EBP-δ in human intestinal epithelial cells. Biochem Biophys Res Commun 2002; 290:469-474.
  • Pritts TA, Wang Q, Sun X, Fischer D, Hungness ES, Fischer JE, Wong HR, Hasselgren PO. The stress response decreases NF-κB activation in liver of endotoxemic mice. Shock 2002; 18:33-37.
  • Al-Ahmadie H, Hasselgren PO, Yassin R, Mutema G. Co-localized granular cell tumor and infiltrating ductal carcinoma of the breast: a case report and review of the literature. Arch Pathol Lab Med 2002; 126:731-733.
  • Hasselgren PO. Stress and muscle cachexia. J Anim Sci 2002; 80 (E.Suppl.2):E50-E55.
  • Safa M, Lower EE, Hasselgren PO, Hungness ES, Gazder P, Aron B, Shaughnessy EA, Yassin R. Bilateral synchronous breast cancer and Her-2/neu overexpression. Breast Cancer Res Treat 2002; 72(3): 195-201.
  • Pritts TA, Hungness ES, Hershko DD, Robb BW, Sun X, Luo GJ, Fischer JE, Wong HR, Hasselgren PO. Proteasome inhibitors induce heat shock response and increase IL-6 expression in human intestinal epithelial cells. Am J Physiol 2002; 282:R1016-R1026.
  • Pritts TA, Hungness E, Wang Q, Robb B, Hershko D, Hasselgren PO. Mucosal and enterocyte IL-6 production during sepsis and endotoxemia. Role of transcription factors and regulation by the stress response. Am J Surg 2002; 183: 372-383.
  • Hasselgren PO, Azizkhan RG, Bower RH, Hurst JM, McDonough JJ, Neale HW, Warden G. Festschrift for Josef E Fischer. Am J Surg 2002; 183: 325-492.
  • Hungness ES, Luo G, Pritts TA, Sun X, Robb BW, Hershko D, Hasselgren PO. The transcription factors C/EBP-β and δ regulate IL-6 production in IL-1β-stimulated human enterocytes. J Cell Physiol 2002; 192: 64-70.
  • Wray CJ, Sun X, Gang G, Hasselgren PO. Dantrolene downregulates the gene expression and activity of the ubiquitin-proteasome proteolytic pathway in septic skeletal muscle. J Surg Res 2002; 104:82-87.
  • Hungness ES, Robb BW, Seeskin C, Hasselgren PO, Luchette FA: Early debridement for necrotizing pancreatitis – is it worthwhile? J Am Coll Surg 2002; 194: 740-745.
  • Robb BW, Hershko DD, Paxton JH, Luo GJ, Hasselgren PO: Interleukin-10 activates the transcription factor C/EBP and the interleukin-6 gene promoter in human intestinal epithelial cells. Surgery 2002; 132: 226-231.
  • Hershko D, Robb BW, Hungness ES, Luo G, Guo X, Hasselgren PO. Arsenite inhibits IL-6 production by downregulating NF-κB activity in IL-1β-stimulated intestinal epithelial cells. Clin Sci 2002; 103:381-390.
  • O’Brien DP, Nelson, LA, Kemp CJ, Williams JL, Wang Q, Erwin CR, Hasslegren PO, Warner BW. Intestinal permeability and bacterial translocation are uncoupled after small bowel resection. J Pediatr Surg 2002; 37:390-394.
  • Fang CH, Li BG, Wray CJ, Hasselgren PO. IGF-1 inhibits lysosomal and proteasome-dependent proteolysis in skeletal muscle after burn injury. J Burn Care Rehab 2002; 23: 318-325.
  • Wray CJ, Tomkinson B, Robb BW, Hasselgren PO. Tripeptidyl peptidase II expression and activity are increased in skeletal muscle during sepsis. Biochem Biophys Res Commun 2002; 296:41-47.
  • Hungness ES, Robb BW, Luo GJ, Hershko DD, Hasselgren PO. Hyperthermia-induced heat shock activates the transcription factor C/EBP-β and augments IL-6 production in human intestinal epithelial cells. J Am Coll Surg 2002; 195:619-626.
  • Hershko DD, Robb BW, Luo GJ, Hasselgren PO. Multiple transcription factors regulating the IL-6 gene are activated by cAMP in cultured Caco-2 cells. Am J Physiol 2002; 283;R1140-R1148.
  • Wray CJ, Mammen JMV, Hasselgren PO. The catabolic response to stress and potential benefits of nutritional support. Nutrition 2002; 18:971-977.
  • Hasselgren PO. Molecular regulation of muscle wasting. Science and Medicine 2002;8: 230-239.
  • Wray CJ, Mammen JMV, Hershko D, Hasselgren PO. Sepsis upregulates the gene expression of multiple ubiquitin ligases in skeletal muscle. Int J Biochem Cell Biol 2003; 35: 698-705.
  • Hershko DD, Robb BW, Luo G, Paxton JH, Hasselgren PO. Interleukin-6 induces thermotolerance in cultured Caco-2 cells independent of the heat shock response. Cytokine 2003; 21:1-9.
  • Luo GJ, Hershko DD, Robb BW, Wray CJ, Hasselgren PO. IL-1β stimulates IL-6 production in cultured skeletal muscle cells through activation of MAP kinase signaling pathway and NFκB. Am J Physiol 2003; 284: R1249-R1254.
  • Sun X, Wray CJ, Tian X, Hasselgren PO, Lu J. The expression of uncoupling protein 3 is upregulated in skeletal muscle during sepsis. Am J Physiol 2003; 285: E512-E520.
  • Hershko DD, Robb BW, Luo GJ, Hungness ES, Hasselgren PO. Sodium arsenite downregulates transcriptional activity of AP-1 and CRE binding proteins in IL-1β-treated Caco-2 cells by increasing the expression of the transcriptional repressor CREMα. J Cell Biochem 2003; 90: 627-640.
  • Pritts TA, Hungness ES, Hasselgren PO. Protein metabolism in liver and intestine during sepsis: Mediators, molecular regulation, and clinical implications. In: Latifi R and Dudrick SJ, eds. The Biology and Practice of Current Nutritional Support, 2nd Edition. Texas: R.G. Landes Bioscience Publishing Company, 2003:103-125.
  • Hasselgren PO. Surgery in Sweden at the time of Halsted. Arch Surg 2004;139: 100-112.
  • Li BG, Hasselgren PO, Fang CH, Warden, DG. Insulin-like growth factor-I blocks dexamethasone-induced protein degradation in cultured myotobes by inhibiting multiple proteolytic pathways. J Burn Care Rehab 2004; 25: 112-118.
  • Hershko DD, Robb BW, Wray CJ, Luo G-J, Hasselgren PO. Superinduction of IL-6 by cycloheximide is associated with mRNA stabilization and sustained activation of p38 MAP kinase and NF-κB in cultured Caco-2 cells. J Cell Biochem 2004; 91: 951-961.
  • Menconi M, Wei W, Yang H, Wray C, Hasselgren PO. Treatment of cultured myotubes with the calcium ionophore A23187 increases proteasome activity via a CaMK-II-caspase-calpain-dependent mechanism. Surgery 2004; 136: 135-142.
  • Cai D, Frantz JD, Tawa NE, Melendez PA, Lidow HGW, Hasselgren PO, Frontera WR, Lee J, Glass DJ, Shoelson SE. Iκκβ/NF-κB activation causes severe muscle wasting in mice. Cell 2004;119:285-298.
  • Yang H, Menconi M, Wei W, Petkova V, Hasselgren PO. Dexamathasone upregulates the expression and activity of the nuclear cofactor p300 and its interaction with C/EBPβ in cultured myotubes. J Cell Biochem 2005; 94: 1058-1067.
  • Yang H, Mammen J, Wei W, Menconi M, Evenson A, Fareed M, Petkova V, Hasselgren PO. The expression and activity of C/EBPβ and δ are upregulated by dexamethasone in skeletal muscle. J Cell Physiol. 2005;204: 219-226.
  • Wei W, Fareed M, Evenson A, Menconi M, Yang H, Petkova V, Hasselgren PO. Sepsis stimulates calpain activity in skeletal muscle by decreasing calpastatin activity but does not activate caspase-3. Am J Physiol 2005;288:R580-R590.
  • Fang CH, Li BG, James JH, King JK, Evenson AR, Warden GD, Hasselgren PO. Protein breakdown in muscle from burned rats is blocked by IGF-I and GSK-3β inhibitors. Endocrinology 2005; 146: 3141-3149.
  • Li BG, Hasselgren PO, Fang CH. Insulin-like growth factor I inhibits dexamethasome-induced proteolysis in L6 myotubes through PI3K/GSK3β and PI3K/mTOR signaling pathways. Int J Biochem Cell Biol 2005; 37: 2207-2216.
  • Hasselgren PO, Menconi MJ, Fareed MU, Yang H, Wei W, Evenson AR. Novel aspects on the regulation of muscle wasting in sepsis. Int J Biochem Cell Biol 2005;37:2156-2168.
  • Hasselgren PO, Attaix D. Muscle wasting: current progress and future aims. Int J Biochem Cell Biol. 2005;37:1932.
  • Mitchell JC, Grant F, Evenson AR, Parker JA, Hasselgren PO, Parangi S. Pre-operative evaluation of thyroid nodules with 18FDG-PET/CT. Surgery 2005;138:1166-1175.
  • Evenson AR, Fareed MU, Menconi MJ, Mitchell JC, Hasselgren PO. GSK-3β inhibitors reduce protein degradation in muscles from septic rats and in dexamethasone-treated myotubes. Int J Biochem Cell Biol 2005; 37: 2226-2238.
  • Fareed MU, Evenson AR, Wei W, Menconi M, Poylin V, Petkova V, Pignol B, Hasselgren PO. Treatment of rats with calpain inhibitors prevents sepsis-induced muscle proteolysis independent of atrogin-1/MAFbx and MuRF1 expression. Am J Physiol 2006;290:R1589-R1597.
  • Wei W, Yang H, Cao P, Menconi MJ, Chamberlain C, Petkova V, Hasselgren PO. The degradation of C/EBPβ in cultured myotubes is calpain-dependant. J Cell Physiol 2006;208:386-398.
  • Evenson A, Mitchell J, Wei W, Poylin V, Parangi S, Hasselgren PO. The gene expression and activity of calpains and the muscle wasting-associated ubiquitin ligases atrogin-1 and MuRF1 are not altered in patients with primary hyperparathyroidism. Int J Mol Med 2006;18:471-475.
  • Yang H, Wei W, Menconi M, Hasselgren PO. Dexamethasone-induced protein degradation in cultured myotubes is p300/HAT-dependent. Am J Physiol 2007;292:R337-R344.
  • Wei W, Yang H, Menconi M, Cao P, Chamberlain CE, Hasselgren PO. Treatment of cultured myotubes with the proteasome inhibitor β-lactone increases the expression of the transcription factor C/EBPβ. Am J Physiol 2007;292:C216-C226.
  • Evenson A, Mowschenson P, Connolly J, Wong H, Parangi S, Hasselgren PO. Hyalinizing trabecular adenoma – an uncommon thyroid tumor frequently misdiagnosed as papillary or medullary thyroid carcinoma. Am J Surg 2007;193:707-712.
  • Reilly N, Poylin V, Menconi M, Onderdonk A, Bengmark S, Hasselgren PO. Probiotics potentiate IL-6 production in IL-1β-treated Caco-2 cells through a heat shock-dependent mechanism. Am J Physiol 2007;293:R1169-R1179.
  • Fang CH, Li B, James JH, Yahya A, Kadeer N, Guo X, Xiao C, Supp DM, Kagan RJ, Hasselgren PO, Sheriff S. GSK-3β activity is increased in skeletal muscle after burn injury in rats. Am J Physiol 2007;293:R1545-R1551.
  • Menconi M, Fareed M, O’Neal P, Poylin V, Wei W, Hasselgren PO. Role of glucocorticoids in the molecular regulation of muscle wasting. Crit Care Med Suppl, 2007;35:S602-S608.
  • Hasselgren PO. Ubiquitination, phosphorylation, and acetylation – triple threat in muscle wasting. J Cell Physiol, 2007;213:679-689.
  • Hasselgren PO. Transcription factors and nuclear cofactors in muscle wasting. In: JL Vincent, ed. Yearbook of Intensive Care and Emergency Medicine. Springer-Verlag (Heidelberg, Germany) 2007;229-237.
  • Hasselgren PO, Hubbard WJ, Chaudry I. Metabolic and inflammatory responses to trauma and infection. In: Fischer JE, editor. Mastery of Surgery, 5th edition, 2007;2-23.
  • Poylin V, Fareed MU, O’Neal P, Alamdari N, Reilly N, Menconi M, Hasselgren PO. The NF-kB inhibitor curcumin blocks sepsis-induced muscle proteolysis. Mediat Inflam 2008; 2008:317851.
  • Menconi M, Gonnella P, Petkova V, Lecker S, Hasselgren PO. Dexamethasone and corticosterone induce similar, but not identical muscle wasting responses in cultured L6 and C2C12 myotubes. J Cell Biochem 2008; 105:353-364.
  • Smith IJ, Lecker SH, Hasselgren PO. Calpain activity and muscle wasting in sepsis. Am J Physiol 2008;295:E762-E771.
  • Goldfarb M, O’Neal P, Shih J, Hartzband P, Connolly J, Hasselgren PO. Synchronous parathyroid carcinoma, parathyroid adenoma, and papillary thyroid carcinoma in a patient with severe and longstanding hyperparathyroidism. Endocr Pract 2009; 15:463-468.
  • O’Neal PB, Poylin V, Mowschenson P, Parangi S, Horowitz G, Pant P, Hasselgren PO. When initial postexcision PTH level does not fall appropriately during parathyroidectomy – what to do next? World J Surg 2009; 33:1665-1673.
  • O’Neal P, Alamdari N, Smith I, Poylin V, Menconi M, Hasselgren PO. Experimental hyperthyroidism in rats increases the expression of the ubiquitin ligases atrogin-1 and MuRF1 and stimulates multiple proteolytic pathways in skeletal muscle. J Cell Biochem 2009; 108:963-973.
  • Alamdari N, O’Neal P, Hasselgren PO. Curcumin and muscle wasting – a new role for an old drug? Nutrition 2009;25:125-129.
1990s
  • Warner BW, Hasselgren PO, Hummel RP, Pedersen P, James JH, Fischer JE. Effect of catabolic hormone infusion on protein turnover and amino acid uptake in skeletal muscle. Am J Surg 1990; 159:295-300.
  • Nordström G, Säljö A, Li S, Hasselgren PO. Effects of ischemia and reperfusion on protein synthesis in liver with different glutathione levels. Ann Surg 1990; 211:97-102.
  • Warner BW, Hasselgren PO, James JH, Hummel RP, Rigel DF, Fischer JE. Reduced amino acid transport in skeletal muscle caused by a circulating factor during endotoxemia. Ann Surg 1990; 211:323-328.
  • James JH, Hasselgren PO, Hummel RP, Warner BW, Fischer JE. Effect of sepsis on amino acid transport system A and its response to insulin in incubated rat skeletal muscle. Metabolism 1990; 39:335-340.
  • Hasselgren PO, James JH, Benson DW, Li S, Fischer JE. Is there a circulating proteolysis inducing factor during sepsis? Arch Surg 1990; 125:510-514.
  • Hasselgren PO, Hall Angerås M, Angerås U, Benson DW, James JH, Fischer JE. Regulation of total and myofibrillar protein breakdown in rat extensor digitorum longus and soleus muscle incubated flaccid or at resting length. Biochem J 1990; 267:37-44.
  • Hall Angerås M, Angerås U, Hasselgren PO, Fischer JE. Effects of elevated temperature on total and myofibrillar protein breakdown in incubated muscles from septic rats. Am J Physiol 1990; 258:C589-C592.
  • Hall Angerås M, Angerås U, Hasselgren PO, Fischer JE. Corticosterone alone does not explain increased muscle proteolysis in septic rats. J Surg Res 1990; 48:368-372.
  • Hasselgren PO, Angerås U, Hall Angerås M. Cytokines and regulation of muscle proteolysis during sepsis. Nutrition Clinique et Metabolisme 1990; 4:99-104.
  • Nordström G, Winsö O, Biber B, Hasselgren PO. Influence of pentobarbital and chloralose on metabolic and hemodynamic changes in liver ischemia. Ann Surg 1990; 212:23-29.
  • von Allmen D, Hasselgren PO, Fischer JE. Hepatic protein synthesis in a modified septic rat model. J Surg Res 1990; 48:476-480.
  • Hall Angerås M, Angerås U, Zamir O, Hasselgren PO, Fischer JE. Interaction between corticosterone and tumor necrosis factor stimulated protein breakdown in rat skeletal muscle, similar to sepsis. Surgery 1990; 108:460-466.
  • Hasselgren PO, Zamir O, James JH, Fischer JE. Prostaglandin E2 does not regulate total or myofibrillar protein breakdown in incubated skeletal muscle from normal or septic rats. Biochem J 1990; 270:45 50.
  • von Allmen D, Hasselgren PO, Higashiguchi T, Zamir O, Fischer JE. Increased intestinal protein synthesis during sepsis. Surg Forum 1990; 41:68 70.
  • Hall Angerås M, Hasselgren PO, Angerås U, Zamir O, Fischer JE. Glucocorticoid receptor blocker RU 38486 decreases muscle protein breakdown in sepsis. Surg Forum 1990; 41:26 27.
  • Hall Angerås M, Angerås U, Zamir O, Hasselgren PO, Fischer JE. Effect of the glucocorticoid receptor antagonist RU 38486 on muscle protein breakdown in sepsis. Surgery 1991; 109:468 473.
  • Fischer JE, Hasselgren PO. Cytokines and glucocorticoids in the regulation of the “hepato-skeletal muscle axis” in sepsis. Am J Surg 1991; 161:266 271.
  • Hiyama D, von Allmen D, Rosenblum L, Ogle CK, Hasselgren PO, Fischer JE. Synthesis of albumin and acute phase proteins in perfused liver following burn injury in rats. J Burn Care Rehabil 1991; 12:1 6.
  • Hall Angerås M, Hasselgren PO, Dimlich RVW, Fischer JE. Myofibrillar proteinase, cathepsin B, and protein breakdown rates in skeletal muscle from septic rats. Metabolism 1991; 40:302 306.
  • Hall Angerås M, Angerås U, von Allmen D, Higashiguchi, T, Zamir O, Hasselgren PO, Fischer JE. Influence of sepsis in rats on muscle protein turnover in vivo and in tissue incubated under different in vitro conditions. Metabolism 1991; 40:247 251.
  • von Allmen D, Li S, Hasselgren PO, Fischer JE. Effect of ischemia on protein synthesis in septic liver. Surg Gynecol Obstet 1991; 172:441 448.
  • Hasselgren PO, Hummel R, Fieler MA. Breast biopsy with needle localization. Influence of age and mammographic features on the rate of malignancy in 350 nonpalpable breast lesions. Surgery, 1991; 110:623 628.
  • Hasselgren PO, Tricoli JV, Wieczorek D, Steigerwald KA, Angerås U, Hall Angerås M, Fischer JE. Reduced levels of mRNA for myofibrillar proteins in skeletal muscle from septic rats. Life Sciences, 1991; 49:753 760.
  • Angerås U, Hall Angerås M, Wagner KR, James JH, Hasselgren PO, Fischer JE. Tissue metabolite levels in different types of skeletal muscle during sepsis. Metabolism 1991; 40:1147-1151.
  • Zamir O, Hasselgren PO, von Allmen D, Fischer JE. The effect of interleukin 1alpha and the glucocorticoid receptor blocker RU 38486 on total and myofibrillar protein breakdown in skeletal muscle. J Surg Res 1991; 50:579-583.
  • Zamir O, James JH, Hasselgren PO, Higashiguchi T, Frederick JA, Fischer JE. The effects of endotoxemia and cytokines on amino acid transport in skeletal muscle and the possible role of glucocorticoids. Surg Forum 1991; 42:101-102.
  • Hasselgren PO, von Allmen D, Fischer JE. Concepts of protein metabolism in liver during sepsis. In: Shock, Sepsis and Organ Failure. Second Wiggers Bernard Conference. New York: Springer Verlag, 1991:207 230.
  • Fischer JE, Hasselgren PO. Hepato skeletal muscle axis: regulation by steroids and cytokines. In: Bengtsson F, et al, eds. Progress in Hepatic Encephalopathy and Metabolic Nitrogen Exchange. Boca Raton, FL: CRC Press, Inc., 1991:323 532.
  • Sax HC, Hasselgren PO. Indications. In: Fischer JE, ed. Total Parenteral Nutrition, 2nd Edition. Boston: Little, Brown and Company, 1991:3 11.
  • Zamir O, Hasselgren PO, Kunkel SL, Frederick JA, Higashiguchi T, Fischer JE. Evidence that tumor necrosis factor participates in the regulation of muscle proteolysis during sepsis. Arch Surg 1992; 127:170-174.
  • Zamir O, Hasselgren PO, Higashiguchi T, Frederick JA, Fischer JE. Effect of sepsis or cytokine administration on release of gut peptides. Am J Surg 1992; 163:181-185.
  • Hasselgren PO, Fidler JP. Further evidence against the routine use of parathyroid ultra-sonography prior to initial neck exploration for hyperparathyroidism. Am J Surg 1992; 167:337-340.
  • Zamir O, Hasselgren PO, Frederick JA, Fisher JE. Is the metabolic response to sepsis in skeletal muscle different in infants and adults? An experimental study in rats. J Pediatric Surg 1992; 27:1399-1403.
  • von Allmen D, Hasselgren PO, Higashiguchi T, Fischer JE Individual regulation of different hepatocellular functions during sepsis. Metabolism 1992; 41:961-965.
  • Hasselgren PO, Fischer JE. Regulation by insulin of muscle protein metabolism during sepsis and other catabolic conditions. Nutrition 1992; 8:434-439.
  • von Allmen D, Hasselgren PO, Higashiguchi T, Frederick JA, Zamir O, Fischer JE. Increased intestinal protein synthesis during sepsis and following administration of tumor necrosis factor alpha (TNFα) or interleukin 1alpha (IL 1α). Biochem J 1992; 286:585-589.
  • Zamir O, Hasselgren PO, Higashiguchi T, Frederick JA, Fischer JE. Tumor necrosis factor (TNF) and interleukin 1 (IL 1) induce muscle proteolysis through different mechanisms. Med Inflam 1992; 1:247-250.
  • Zamir O, Hasselgren PO, O’Brien W, Thompson R, Fischer JE. Muscle protein breakdown during endotoxemia in rats and after treatment with interleukin-1 receptor antagonist (IL-1ra). Ann Surg 1992; 216:381-387.
  • Higashiguchi T, Frederick JA, Zamir O, Hasselgren PO, Fischer JE. Effect of glutamine on protein synthesis in isolated enterocytes from septic rats. Surg Forum 1992; 43:26-28.
  • Hasselgren PO, Fischer JE. Recent advances on the regulation of muscle protein metabolism in catabolic states. With special reference to the role of cytokines and glucocorticoids for protein breakdown during sepsis. RINPE 1992; 10:72-84.
  • Hasselgren PO, Fischer JE. Cytokines and protein metabolism. With special reference to the regulation of muscle protein breakdown during sepsis. In: 11th Ross Conference on Medical Research. Columbus, OH: Ross Laboratories, 1992:39-46.
  • Zamir O, Hasselgren PO, von Allmen D, Fischer JE. In vivo administration of interleukin 1α induces muscle proteolysis in normal and adrenalectomized rats. Metabolism 1993; 42:204-208.
  • Frederick JA, Hasselgren PO, Davis S, Higashiguchi T, Jacob TD, Fischer JE. Nitric oxide may upregulate in vivo hepatic protein synthesis during endotoxemia. Arch Surg 1993; 128:152-157.
  • Zamir O, James JH, Higashiguchi T, Hasselgren PO, Fischer JE. Effect of tumor necrosis factor (TNF) and interleukin 1 (IL 1) on muscle amino acid uptake and the role of glucocorticoids. Surg Gynecol Obstet 1993; 177:27-32.
  • Guenther JM, Tennenberg SD, Hasselgren PO. Pancreaticoduodenal artery aneurysm: An uncommon etiology of recurrent gastrointestinal bleeding. Contemporary Surgery for Residents 1993; 1:25-28.
  • Higashiguchi T, Hasselgren PO, Wagner K, Fischer JE. Effect of glutamine on protein synthesis in isolated intestinal epithelial cells. JPEN 1993; 17:307-314.
  • O’Brien W, Hasselgren PO, Hummel RP, Coith R, Hyams D, Kurtzman L, Neale HW. Comparison of postoperative complications in patients undergoing mastectomy for cancer with or without immediate breast reconstruction. Am J Surg 1993; 166:1-5.
  • Higashiguchi T, Noguchi T, Kanarada Y, Mizumoto R, Hasselgren PO, Fischer JE. Effect of nutritional management for the alteration of protein and amino acid metabolism in liver, skeletal muscle and gut during sepsis in cirrhosis. Jap J Gastroenterol Surg 1993; 26:1157-1162.
  • Zamir O, James JH, Hasselgren PO, Fischer JE. Evidence that inhibition of muscle amino acid uptake during endotoxemia is not mediated by glucocorticoids. Metabolism 1993; 42:1190-1194.
  • Hasselgren, PO. Protein metabolism in sepsis. Georgetown, TX: Medical Intelligence Unit, RG Landes, 1993.
  • Tiao G, Noguchi Y, James JH, Hasselgren PO, Fischer JE. Polyamine synthesis in liver increases during sepsis and following administration of TNF or IL-1. Surg Forum 1993; 44:4-6.
  • Hasselgren PO, Hummel RP, Georgian-Smith D, Fieler M. Breast biopsy with needle localization: accuracy of specimen x-ray and management of missed lesions. Surgery 1993; 114:836-842.
  • James JH, Hasselgren PO, King JK, James LE, Fischer JE. Intracellular glutamine levels do not decrease in all muscles during sepsis. J Surg Res 1993; 54:558-564.
  • Hasselgren PO. Hormones and cytokines in the regulation of muscle proteolysis during sepsis. Basic and Applied Myology 1993; 3: (2) 143-156.
  • Tiao G, Rafferty JF, Ogle C, Fischer JE, Hasselgren PO. Detrimental effect of nitric oxide synthase inhibition during endotoxemia may be caused by high levels of TNF and IL-6. Surgery 1994; 116:332-338.
  • Higashiguchi T, Noguchi Y, Noffsinger A, Fischer JE, Hasselgren PO. Sepsis increases production of total secreted proteins, vasoactive intestinal peptide (VIP), and peptide YY (PYY) in isolated rat enterocytes. Am J Surg 1994; 168:251-256.
  • Zamir O, O’Brien W, Thompson R, Bloedow DC, Fischer JE, Hasselgren PO. Reduced muscle protein breakdown in septic rats following treatment with interleukin 1 receptor antagonist. Int J Biochem 1994; 26:943-950.
  • Rafferty JA, Noguchi Y, Fischer JE, Hasselgren PO. Sepsis in rats stimulates cellular proliferation in small intestine. Gastroenterology 1994; 107:121-127.
  • Higashiguchi T, Noguchi Y, O’Brien W, Wagner K, Fischer JE, Hasselgren PO. Effect of sepsis in rats on mucosal protein synthesis in different parts of the gastrointestinal tract. Clin Sci 1994; 87:207-211.
  • Fang CH, Tiao G, Fischer JE, Hasselgren PO. Differential expression of ubiquitin mRNA in red and white skeletal muscle reflects differences in sepsis-induced muscle proteolysis. Surg Forum 1994; 45:41-43.
  • Tiao G, Fagan JM, Samuels N, James JH, Hudson K, Lieberman M, Fischer JE, Hasselgren PO. Sepsis stimulates non-lysosomal energy-dependent proteolysis and increases ubiquitin mRNA levels in rat skeletal muscle. J Clin Invest 1994; 94:2255-2264.
  • Meyer TA, Noguchi Y, Ogle C, Tiao G, Wang JJ, Fischer JE, Hasselgren PO. Endotoxin stimulates IL-6 production in intestinal epithelial cells: a synergistic effect with PGE2. Arch Surg 1994; 129:1290-1295.
  • Fang CH, James JH, Ogle C, Fischer JE, Hasselgren PO. Influence of burn injury on protein metabolism in different types of skeletal muscle and the role of glucocorticoids. J Am Coll Surg 1995; 180:33-42.
  • Fang CH, Tiao G, James H, Ogle C, Fischer JE, Hasselgren PO. Burn injury stimulates multiple proteolytic pathways in skeletal muscle, including the ubiquitin-energy-dependent pathway. J Am Coll Surg 1995; 180:161-170.
  • Chance WT, Noguchi Y, Zhang X, Hasselgren PO, Fischer JE. Differential effects of tumor and parenteral nutrition on jejunal mucosal polyamines. Nutr Cancer 1995; 23:23-32.
  • Fang CH, James JH, Fischer JE, Hasselgren, PO. Is muscle protein turnover regulated by intracellular glutamine during sepsis? JPEN 1995; 19:279-285.
  • Meyer T, Tiao G, James JH, Noguchi Y, Ogle CK, Fischer JE, Hasselgren PO. Nitric oxide inhibits LPS-induced IL-6 production in enterocytes. J Surg Res 1995; 58:570-575.
  • Meyer TA, Wang J, Tiao G, Ogle CK Fischer JE, Hasselgren PO. Sepsis and endotoxemia stimulate intestinal IL-6 production. Surgery 1995; 118:336-342.
  • Higashiguchi T, Noguchi Y, Meyer T, Fischer JE, Hasselgren PO. Protein synthesis in isolated enterocytes from septic or endotoxemic rats: Regulation by glutamine. Clin Sci 1995; 89:311-319.
  • Tiao G, Fagan J, Lieberman M, Fischer JE, Hasselgren PO. Sepsis increases proteasome-dependent proteolysis and mRNA levels for the proteasome subunit RC3 in skeletal muscles. Surg Forum 1995; 46:10-12.
  • Meyer TA, Wang JJ, Tiao G, Ogle CK, Fischer JE, Hasselgren PO. Sepsis and endotoxemia increase expression of IL-1 and IL-6 in the central nervous system (CNS). Surg Forum 1995; 46:1-3.
  • Molina P, Tiao G, Meijerink J, Hasselgren PO, Abumrad NN. Sepsis-induced increase in brain endogenous morphine: regulator of muscle proteolysis. Surg Forum 1995; 46:4-6.
  • Higashiguchi T, Yokoi H, Noguchi T, Kamarada Y, Mizumoto R, Hasselgren PO. The preoperative nutritional assessment of surgical patients with hepatic dysfunction. Jpn J Surg 1995; 25:113-118.
  • Tiao G, Noguchi Y, Fischer JE, Hasselgren PO. Sepsis stimulates polyamine biosynthesis in the liver and increases tissue levels of ornithine decarboxylase mRNA. Shock 1995; 4:403-410.
  • Hasselgren PO. Muscle protein metabolism during sepsis. Biochem Soc Transactions 1995; 23:1019-1025.
  • Hasselgren PO. Editorial on “Down-regulation of albumin synthesis in the rat by human recombinant interleukin-1β or turpentine and the response to nutrients” by Ballmer PE. McNurlan MA, Grant I, and Garlick PH. JPEN 1995; 19:257.
  • Hasselgren PO, Fischer JE, Meyer T, Tiao G. Inhibition of nitric oxide synthase during endotoxemia may be detrimental. In: Schlag G, Redl H, eds. Shock, Sepsis and Organ Failure – Nitric Oxide. Berlin: Springer Verlag, 1995:198-220.
  • Hasselgren PO. Counter-regulatory hormones and the role of cytokines in the control of amino acid metabolism. In: Cynober L, ed. Amino Acid Metabolism in Health and Nutritional Diseases. Boca Raton, FL: CRC Press, Inc., 1995:139-156.
  • Hasselgren PO. Mediators and Mechanisms of Muscle Catabolism in Sepsis. In: Latifi R, Dudrick SJ, eds. Surgical Nutrition: Strategies in Critically Ill Patients. Texas: R.G. Landes, 1995:1-23.
  • Noguchi Y, Meyer TA, Ogle CK, Fischer JE, Hasselgren PO. Influence of sepsis and endotoxemia on polyamine metabolism in mucosa of small intestine in rats. Metabolism 1996; 45:28-33.
  • Tiao G, Fagan J, Roegner V, Lieberman M, Wang JJ, Fischer JE, Hasselgren PO. Energy-ubiquitin-dependent muscle proteolysis during sepsis in rats is regulated by glucocorticoids. J Clin Invest 1996; 97:339-348.
  • Noguchi Y, Meyer TA, Tiao G, Fischer JE, Hasselgren PO. Sepsis increases putrescine concentration and protein synthesis in mucosa of small intestine in rats. Shock 1996; 5:333-340.
  • Tiao G, Hudson K, Lieberman MA, Fischer JE, Hasselgren PO. Identification of altered gene expression in skeletal muscle during sepsis using differential display. J Surg Res 1996; 64:63-67.
  • Parikh AA, Salzman A, Fischer JE, Hasselgren PO. Interleukin-6 (IL-6) production in human intestinal epithelial cells is regulated by interleukin-1β (IL-1β) and interferon-γ (IFNγ). Surg Forum 1996; 47:3-7.
  • Hobler S, Tiao G, Fischer JE, Hasselgren PO. The sepsis-induced increase in muscle proteolysis is associated with increased 20S proteasome activity and is blocked by 20S proteasome inhibitors. Surg Forum 1996; 47:14-17.
  • O’Brien WJ, Lingrel JB, Fischer JE, Hasselgren PO. Sepsis increases skeletal muscle sodium, potassium-ATPase activity without affecting mRNA or protein levels. J Am Coll Surg 1996; 183:471-479.
  • Ogle CK, Mao JX, Hasselgren PO, Ogle JD, Alexander JW. Production of cytokines and prostaglandin E2 by subpopulations of guinea pig enterocytes: effect of endotoxin and thermal injury. J Trauma 1996; 41:298-305.
  • Espat NJ, Auffenberg T, Rogy M, Fang CH, Hasselgren PO, Copeland EM, Moldawer LL. Ciliary neutrophilic factor is a novel mediator of skeletal muscle catabolism and shares with interleukin-6 the capacity to induce a hepatic acute phase protein response. Am J Physiol 1996; 271:R185-R190.
  • Fagan JM, Ganguly M, Tiao G, Fischer JE, Hasselgren PO. Sepsis increases oxidatively damaged proteins in skeletal muscle. Arch Surg 1996; 131:1326-1332.
  • James JH, Fang CH, Schrantz SJ, Hasselgren PO, Paul RJ, Fischer JE. Linkage of aerobic glycolysis to sodium-potassium transport in rat skeletal muscle. Implications for increased muscle lactate production in sepsis. J Clin Invest 1996; 98:2348-2397.
  • Hasselgren PO. Mediators, hormones, and control of metabolism. Regulation of protein, carbohydrate, and lipid metabolism in critical illness. In: Fischer JF,ed. Nutrition and Metabolism in the Surgical Patient, 2nd edition. Boston: Little, Brown and Company, 1996:57-104.
  • Hasselgren, PO. Protein metabolism in liver and intestine during sepsis: mediators, mechanisms, and clinical implications. In: Latifi R, Dudrick SJ, eds. Current Surgical Nutrition. Texas: R.G. Landes, 1996:113-145.
  • Hasselgren PO, Meyer T. Enteral nutrition and protein metabolism. In: Rombeau J, Rolandelli R, eds. Clinical Nutrition: Enteral and Tube Feeding, 3rd Edition. Philadelhpia: Saunders Company, 1996:23-46.
  • Hasselgren PO, Tiao G. Metabolic response to trauma and infection. In: LM Nyhus, RJ Baker, JE Fischer, eds. Mastery of Surgery, 3rd Edition. Boston: Little, Brown and Company, 1996:3-21.
  • Wang Q, Fischer JE, Hasselgren PO. Treatment of endotoxemic mice with anti-IL-6 antibody paradoxically increases IL-6 levels and stimulates mucosal protein synthesis. Arch Surg 1997; 132:82-88.
  • Ogle CK, Guo X, Hasselgren PO, Ogle JD, Alexander JW. The gut as a source of inflammatory cytokines after stimulation with endotoxin. Europ J Surg 1997; 163:45-51.
  • Tiao G, Hobler S, Wang JJ, Meyer TA, Luchette FA, Fischer JE, Hasselgren PO. Sepsis is associated with increased mRNAs of the ubiquitin-proteasome proteolytic pathway in human skeletal muscle. J Clin Invest 1997; 99:163-168.
  • Tiao G, Lieberman MA, Fischer JE, Hasselgren PO. Intracellular regulation of protein degradation during sepsis is different in fast- and slow-twitch muscle. Am J Physiol 1997; 272:R849-R856.
  • Noguchi Y, James H, Fischer JE, Hasselgren PO. Increased glutamine consumption in small intestine epithelial cells during sepsis in rats. Am J Surg 1997; 172:199-205.
  • Meyer TA, Wang JJ, Tiao GM, Ogle CK, Fischer JE, Hasselgren PO. Sepsis and endotoxemia stimulate expression of IL-1 and IL-6 in the central nervous system. Clin Sci 1997; 92:519-525.
  • Parikh A, Salzman A, Kane CD, Fischer JE, Hasselgren PO. IL-6 production in human intestinal epithelial cells following stimulation with IL-1β is associated with activation of the transcription factor NF-κB. J Surg Res 1997; 69:139-144.
  • Fang CH, Li BG, Wang JJ, Fischer JE, Hasselgren PO. Insulin-like growth factor-I (IGF-I) stimulates protein synthesis and inhibits protein breakdown in muscle from burned rats. JPEN 1997; 21:245-251.
  • Fang CH, Li BG, James JH, Fischer JE, Hasselgren PO. Cytokines block the effects of IGF-I on glucose uptake and lactate production in skeletal muscle but do not influence IGF-I-induced changes in protein turnover. Shock 1997; 8:362-367.
  • Parikh A, Salzman A, Fischer JE, Hasselgren PO. Interleukin-1β and interferon-γ regulate interleukin-6 production in human intestinal epithelial cells. Shock 1997; 8:249-255.
  • Hobler S, Wang JJ, Fischer JE, Hasselgren PO. Sepsis is associated with increased expression of the 14kDa ubiquitin-conjugating enzyme (E2) in skeletal muscle. Surg Forum 1997; 48:1-3.
  • Parikh A, Moon MR, Fischer JE, Salzman AL, Hasselgren PO. Serine protease activity is required for interleukin-1-β-induced NF-κB activation in human intestinal epithelial cells. Surg Forum 1997; 48:38-41.
  • Moon R, Parikh AA, Szabo C, Fischer JE, Salzman AL, Hasselgren PO. Complement C3 production in human intestinal epithelial cells is regulated by IL-1β and TNF-α. Arch Surg 1997; 132:1289-1293.
  • Hasselgren PO, Fischer JE. The ubiquitin-proteasome pathway: review of a novel intracellular mechanism of muscle protein breakdown during sepsis and other catabolic conditions. Ann Surg 1997; 225:307-316.
  • Fang CH, Li BG, Tiao G, Wang JJ, Fischer JE, Hasselgren PO. The molecular regulation of protein breakdown following burn injury is different in fast- and slow-twitch skeletal muscle. Int J Mol Med 1998; 1:163-169.
  • Hasselgren PO, Fischer JE. Sepsis: stimulation of energy-dependent protein breakdown resulting in protein loss in skeletal muscle. World J Surg 1998; 22:203-208.
  • Hobler SC, Tiao G, Fischer JE, Monaco J, Hasselgren PO. The sepsis-induced increase in muscle proteolysis is blocked by specific proteasome inhibitors. Am J Physiol 1998; 274:R30-R37.
  • Hobler SC, Williams A, Fischer JE, Hasselgren PO. Insulin-like growth factor I (IGF-I) stimulates protein synthesis but does not inhibit protein breakdown in muscle from septic rats. Am J Physiol 1998; 274:R571-R576.
  • Fang CH, Wang JJ, Hobler S, Li BG, Fischer JE, Hasselgren PO. Proteasome blockers inhibit protein breakdown in skeletal muscle after burn injury in rats. Clin Sci 1998; 95:225-233.
  • Parikh AA, Moon MR, Kane CD, Salzman AL, Fischer JE, Hasselgren PO. Interleukin-6 production in human intestinal epithelial cells increases in association with the heat shock response. J Surg Res 1998; 77:40-44.
  • Wang Q, Wang JJ, Boyce S, Fischer JE, Hasselgren PO. Endotoxemia and IL-1β stimulate mucosal IL-6 production in different parts of the gastrointestinal tract. J Surg Res 1998; 76:27-31.
  • Fang CH, Li BG, James JH, Fischer JE, Hasselgren PO. The anabolic effects of IGF-I in skeletal muscle are not caused by increased cell volume. JPEN 1998; 22:115-119.
  • Fang CH, Li BG, Wang JJ, Fischer JE, Hasselgren PO. Treatment of rats with insulin-like growth factor I inhibits the catabolic response in skeletal muscle following burn injury. Am J Physiol 1998; 275:R1091-R1098.
  • Williams AB, Fischer JE, Hasselgren PO. Ca2+-dependent release of myofilaments increases in skeletal muscle during sepsis. Surg Forum 1998; 49:66-69.
  • Parikh AA, Moon MR, Fischer JE, Salzman AL, Hasselgren PO. Heat shock inhibits activation of the inflammatory transcription factor NF-κB in human intestinal epithelial cells. Surg Forum 1998; 49:112-114.
  • Wang L, Luo GJ, Wang JJ, Hasselgren PO. Dexamethasone stimulates proteasome- and calcium-dependent proteolysis in cultured L6 myotubes. Shock 1998; 10:298-306.
  • Wang Q, Wang JJ, Fischer JE, Hasselgren PO. Mucosal production of complement C3 and serum amyloid A is differentially regulated in different parts of the gastrointestinal tract during endotoxemia in mice. J Gastrointest Surg 1998; 2:537-546.
  • Wang Q, Meyer TA, Boyce S, Wang JJ, Sun X, Tiao G, Fischer JE, Hasselgren PO. Endotoxemia in mice stimulates the production of complement component C3 and serum amyloid A in mucosa of small intestine. Am J Physiol 1998; 275:R1584-R1592.
  • Pritts TA, Moon MR, Fischer JE, Salzman AL, Hasselgren PO. Nuclear factor-κB is activated in intestinal mucosa during endotoxemia. Arch Surg 1998; 133:1311-1315.
  • Williams A, Wang JJ, Wang L, Fischer JE, Hasselgren PO. Sepsis in mice stimulates muscle proteolysis in the absence of IL-6. Am J Physiol 1998; 275:R1983-R1991.
  • Hasselgren PO. The significance of intestinal cytokines. In: Schein M, Wise L, eds. Cytokines and the Abdominal Surgeon. Georgetown, TX: Landes Bioscience, 1998:197-213.
  • Molloy M, Sorrell MJ, Bower RH, Hasselgren PO, Dalton BJ. Patterns of morbidity and resource consumption associated with laparoscopic cholecystectomy in a VA medical center. J Surg Res 1999; 81:15-20.
  • Hobler SC, Wang JJ, Williams AB, Melandri F, Sun X, Fischer, JE, Hasselgren PO. Sepsis is associated with increased ubiquitin conjugating enzyme E214k mRNA in skeletal muscle. Am J Physiol 1999; 276:R468-R473.
  • Moon MR, Parikh AA, Pritts TA, Fischer JE, Cottongim S, Szabo C, Salzman AL, Hasselgren PO. Complement component C3 production in IL-1β-stimulated human intestinal epithelial cells is blocked by NF-κB inhibitors and by transfection with Ser 32/36 mutant IκBalpha. J Surg Res 1999; 82:48-55.
  • Molloy M, Bower RH, Hasselgren PO, Dalton BJ. Cholangiography during laparoscopic cholecystectomy – cumulative sum analysis of an institutional learning curve. J Gastrointest Surg 1999; 3:185-188.
  • Hobler SC, Williams AB, Fischer D, Wang JJ, Sun X, Fischer, JE, Monaco JJ, Hasselgren PO. The activity and expression of the 20S proteasome are increased in skeletal muscle during sepsis. Am J Physiol 1999; 277:R434-R440.
  • Williams A, de Courten-Myers GM, Fischer JE, Luo G, Sun X, Hasselgren PO. Sepsis stimulates release of myofilaments in skeletal muscle by a calcium-dependent mechanism. FASEB J 1999; 13:1435-1443.
  • Fischer DR, Sun X, Pritts TA, Hasselgren PO. The amount of the glucocorticoid receptor (GR) and its hormone binding activity are increased in skeletal muscle during sepsis. Surg Forum 1999; 50:232-234.
  • Wang Q, Hasselgren PO. Interleukin-6 (IL-6) increases intestinal permeability during sepsis. Surg Forum 1999; 50:245-246.
  • Moon MR, Pritts TA, Parikh AA, Fischer JE, Salzman AL, Wong HR, Ryan, M, Hasselgren PO. Stress response decreases the interleukin-1β-induced production of complement component C3 in human intestinal epithelial cells. Clin Sci 1999; 97:331-337.
  • Williams AB, Sun X, Fischer JE, Hasselgren PO. The expression of genes in the ubiquitin-proteasome proteolytic pathway is increased in skeletal muscle from patients with cancer. Surgery 1999; 126:744-750.
  • Hasselgren PO, Fischer JE. Counter-regulatory hormones and mechanisms in amino acid metabolism with special reference to the catabolic response in skeletal muscle. Curr Opin Clin Nutr Metab Care 1999; 2:9-14.
  • Hasselgren PO. What’s new in burns and metabolism? J Am Coll Surg 1999; 188:98-103.
  • Hasselgren PO. Role of the ubiquitin-proteasome pathway in sepsis-induced muscle catabolism. Mol Biol Rep 1999; 26:71-76.
  • Hasselgren PO. Glucocorticoids and muscle catabolism. Curr Opin Clin Nutr Metab Care 1999; 2:201-205.
  • Hasselgren PO. Pathways of muscle protein breakdown in injury and sepsis. Curr Opin Clin Nutr Metab Care 1999; 2:155-160.
1980s
  • Hasselgren PO, Almersjo O, Gustavsson B, Seeman T, von der Decken A. Structural and functional changes in ribosomes from ischemic liver in the dog. Effects of short term hepatic artery ligation and hemorrhagic hypovolemia. Eur Surg Res 1980; 12:30-38.
  • Hasselgren PO, Almersjo O, Gustavsson B, Rosengren K. Amino acid incorporation into liver and tumor proteins in patients with hepatic neoplasms: effects of liver dearterialization. Acta Chir Scand 1980; 146:271-275.
  • Hasselgren PO. Acute pancreatitis in pregnancy. Report of two cases. Acta Chir Scand 1980; 146:297-299.
  • Hasselgren PO, Fornander J, Lundstam S, Saretok T, Seeman T, Säljö A. Postoperative wound infections: a prospective study in a newly opened hospital. Ann Chir Gynecol 1980; 69:269-272.
  • Hasselgren PO, Holm J. Sources and routes in postoperative wound infections. Acta Chir Scand 1981; 147:99-103.
  • Hasselgren PO, Almersjo O, Gustavsson B, Seeman T. Trauma to the liver during a ten year period. With special reference to morbidity and mortality after blunt trauma and stab wounds. Acta Chir Scand 1981; 147:387-393.
  • Hasselgren PO, Almersjo O, Seeman T. Traumatic liver rupture: aspects of surgical treatment. Lakartidningen 1981; 78:4262-4264.
  • Fornander J, Gustavsson B, Hasselgren PO. Post traumatic hemobilia and hepatic artery ligature. Lakartidningen 1981; 78:4566-4567.
  • Hasselgren PO, Fornander J. Effects of liver ischemia on hepatic protein synthesis in vitro and in vivo. Acta Physiol Scand 1982; 114:143-148.
  • Almskog B, Haljamae H, Hasselgren PO, Nordström G, Seeman T. Local metabolic changes in skeletal muscle after high velocity missile injury. J Trauma 1982; 22:382-387.
  • Hasselgren PO, Säljö A, Lundstam S, Seeman T. Postoperative wound infections in patients with long preoperative hospital stay. Acta Chir Scand 1982; 148:473-477.
  • Hasselgren PO, Almskog B, van der Decken A, Seeman T. Leucine incorporation into skeletal muscle proteins in vitro and function of isolated ribosomes from skeletal muscle around a high velocity missile injury. Acta Chir Scand (suppl) 1982; 508:337-344.
  • Hasselgren PO, Jennische E, Fornander J, Hellman A. No effect of ATP MgCl2 on impaired transmembrane potential and protein synthesis in liver ischemia. Acta Chir Scand 1982; 148:601-607.
  • Fornander J, Biber B, Hasselgren PO. Improved blood flow and protein synthesis in the postischemic liver following infusion of dopamine. J Surg Res 1983; 34:44-52.
  • Adlerberth A, Hasselgren PO, Lukes P, Stenstrom G. Adrenal myelolipoma. Report of a case and review of the literature. Ann Chir Gynaecol 1983; 72:76-79.
  • Malmgren S, Hasselgren PO, Hellman A, Seeman T. Increasing incidence of stab wounds. Acta Chir Scand 1983; 149:337-340.
  • Hasselgren PO, Eriksson B, Lukes P, Seeman T. False popliteal aneurysm caused by exostosis of the femur. J Cardiovasc Surg 1983, 24:540-547.
  • Saretok T, Almersjo O, Gustavsson B, Hasselgren PO. Effect of hydralazine on liver blood flow in normovolemic dogs. Acta Chir Scand 1984; 150:1-4.
  • Fornander J, Jagenburg O, Hasselgren PO. Effects of liver ischemia on degradation of different classes of hepatic proteins. Acta Physiol Scand 1984; 120:61-66.
  • Fornander J, Hellman A, Hasselgren PO. Effects of methylprednisolone on protein synthesis and blood flow in the postischemic liver. Circ Shock 1984; 12:287-295.
  • Hasselgren PO, Hulten L, Karlstrom L. “Cancer family syndrome”: description of a family with high incidence of malignant tumors in colon and other organs. Lakartidningen 1984; 81:2451-2453.
  • Almskog B, Haljamae H, Hasselgren PO, Lund B, Seeman T, Van der Decken A. Effects of hypovolemia on local metabolic changes in skeletal muscle following high velocity missile injury. Circ Shock 1984; 12:253-264.
  • Hasselgren PO, Jagenburg R, Karlstrom L, Pedersen P, Seeman T. Changes of protein metabolism in liver and skeletal muscle following trauma complicated by sepsis. J Trauma 1984; 24:224-228.
  • Melberg PE, Styf J, Biber B, Korner L, Hasselgren PO, Seeman T. Muscular compartment pressure following reconstructive arterial surgery of the lower limbs. Acta Chir Scand 1984; 150:129-133.
  • Hasselgren PO, Hellman A, Jennische E, Nordström G. Failure of an increased dose of ATP MgCl2 to improve protein synthesis and transmembrane potential in the postischemic liver. J Surg Res 1984; 37:409-414.
  • Hasselgren PO, Adlerberth A, Angerås U, Stenstrom G. Protein metabolism in skeletal muscle tissue from hyperthyroid patients following preoperative treatment with a β 1 blocking agent. Results from a prospective randomized study. J Clin Endocrinol Metab 1984; 59:835-839.
  • Pedersen P, Biber B, Kajser B, Martinell S, Seeman T, Hasselgren PO. Hemodynamic and hematologic changes in a standardized trauma sepsis model in rats. Circ Shock 1984; 14:13-23.
  • Hasselgren PO, Ivarsson L, Risberg B, Seeman T. Effects of prophylactic antibiotics in vascular surgery: A prospective, randomized, double blind study. Ann Surg 1984; 200:86-92.
  • Hasselgren PO, Hagberg E, Malmer H, Säljö A, Seeman T. One instead of two knives for surgical incision: does it increase the risk of postoperative wound infection? Arch Surg 1984; 119:917-920.
  • Hall Angerås M, Hasselgren PO, Pedersen P. Effect of methylprednisolone and indomethacin on survival after trauma sepsis in rats. Svensk Kirurgi 1984; 42:134.
  • Ullman M, Hasselgren PO. Torsion of an appendix epiploicum on appendix vermiformis. Lakartidningen 1984; 81:3240.
  • Ullman M, Tveit E, Hasselgren PO. Post traumatic and postoperative acute acalculous cholecystitis. Acta Chir Scand 1984; 150:507-509.
  • Hasselgren PO, Hagberg E, Seeman T. One instead of two surgical knives did not increase the risk of postoperative wound infection. Lakartidningen 1984; 81:3689.
  • Niemand D, Abrahamson J, Hasselgren PO. Subdural hematoma after attempted epidural analgesia (case report). Anest Inten Ter 1984; 16:393.
  • Fornander J, Seeman T, Hasselgren PO. Changes of protein synthesis in liver tissue following ligation of hepatic artery or portal vein in rats. Eur Surg Res 1985; 17:101-108.
  • Fornander J, Bergmark J, Jagenburg R, Hasselgren PO. Evaluation of an in vitro method for the study of protein synthesis in liver ischemia. Eur Surg Res 1985; 17:91-100.
  • Angerås U, Hasselgren PO. Effects of experimental hyperthyroidism on protein turnover in different types of skeletal muscle. Acta Endocrinol 1985; 109:90-95.
  • Nordström G, Seeman T, Hasselgren PO. Beneficial effect of allopurinol in liver ischemia. Surgery 1985; 97:679-684.
  • Hasselgren PO, Talamini MA, LaFrance R, James JH, Peters JC, Fischer JE. Effect of indomethacin on proteolysis in septic muscle. Ann Surg 1985; 202:557-562.
  • James JH, Hasselgren PO, Peters JC, Fischer JE. Effect of sepsis on amino acid uptake in incubated skeletal muscles from rats. Surg Forum 1985; 36:56-58.
  • Peters JC, Hasselgren PO, Fischer JE. Is there a role for thyroid hormone in increased muscle proteolysis during sepsis? Surg Forum 1985; 36:78-80.
  • Talamini MA, Hasselgren PO, James JH, Peters JC, Fischer JE. Sequential changes in muscle protein metabolism during sepsis in rats. Surg Forum 1985; 36:81-82.
  • Stockland E, Wihed A, Cedar S, Hasselgren PO, Lukes P, Seeman T. Ultrasound diagnosis of an aneurysm of the common hepatic artery. J Clin Ultrasound 1985; 13:369-370.
  • Hasselgren PO. Letter to the Editor, in reply to letter of Krause R, et al. J Trauma 1985; 25:276-277.
  • Pedersen P, Seeman T, Hasselgren PO. Protein synthesis and degradation in liver tissue following induction of septic peritonitis in rats. Acta Chir Scand 1986; 152:29-34.
  • Hasselgren PO, James JH, Fischer JE. Inhibited muscle amino acid uptake in sepsis. Ann Surg 1986; 203:360-365.
  • Warner BW, Hasselgren PO, Fischer JE. Effect of allopurinol and superoxide dismutase on survival in rats with sepsis. Current Surgery 1986; 43:292-293.
  • Hasselgren PO, Talamini MA, James JH, Fischer JE. Protein metabolism in different types of skeletal muscle during early and late sepsis in rats. Arch Surg 1986; 121:918-923.
  • Hasselgren PO, James JH, Warner BW, Ogle C, Takehara H, Fischer JE. Reduced muscle amino acid uptake in sepsis and the effect in vitro of septic plasma and interleukin 1. Surgery 1986; 100:222-228.
  • Angerås U, Oldfors A, Hasselgren PO: β adrenergic blockade does not influence changes in skeletal muscle fibre type composition or morphology during experimental hyperthyroidism in rats. Acta Pathol Microbiol Immunol Scand (Sect A) 1986; 94:91-99.
  • Angerås U, Jagenburg R, Hasselgren PO. Effects of thyroid hormone and beta blocking agents on plasma amino acids in rats. Acta Chir Scand 1986; 152:339-345.
  • Adlerberth A, Jagenburg R, Lindstedt G, Stenstrom G, Hasselgren PO. Effects of thyroid hormone and β blocking agents on urinary excretion of 3 methylhistidine and plasma amino acids in man. Europ J Clin Invest 1986; 16:316-320.
  • Hasselgren PO, Säljö A, Seeman T. Protein turnover in skeletal muscle tissue from patients with hyperparathyroidism and the effect of calcium in vitro. Europ Surg Res 1986; 18:337-342.
  • Hasselgren PO, James JH, Takehara H, Warner B, Fischer JE. Beta-adrenergic mediated insulin resistance of protein breakdown in septic muscle. Surg Forum 1986; 37:60-61.
  • Hall Angerås M, Hasselgren PO. Effects of methylprednisolone, indomethacin, and diethyl-carbamazine on survival rate following trauma and sepsis in rats. Circ Shock 1986; 20:231-238.
  • Hasselgren PO, Fischer JE. Septic encephalopathy: etiology and management. Intensive Care Medicine 1986; 12:13-16.
  • Hasselgren PO, Warner BW, James JH, Takehara H, Fischer JE. Effect of insulin on amino acid uptake and protein turnover in skeletal muscle from septic rats: evidence for insulin resistance of protein breakdown. Arch Surg 1987; 122:228-233.
  • Angerås U, Jagenburg R, Lindstedt G, Hasselgren PO. Effects of beta adrenergic blocking agents on urinary excretion of 3 methylhistidine during experimental hyperthyroidism in rats. Europ Surg Res 1987; 19:23-30.
  • Adlerberth A, Stenstrom G, Hasselgren PO. The selective beta 1 blocking agent metoprolol compared with antithyroid drug and thyroxine as preoperative treatment of patients with hyperthyroidism. Results from a prospective, randomized study. Ann Surg 1987; 205:182-188.
  • Pedersen P, Säljö A, Hasselgren PO. Protein and energy metabolism in liver tissue following infusion of live E. coli bacteria in rats. Circ Shock 1987; 21:59-64.
  • Angerås U, Hasselgren PO: Protein degradation in skeletal muscle during experimental hyperthyroidism in rats and the effect of β-blocking agents. Endocrinology 1987; 120:1417-1421.
  • Warner BW, James JH, Hasselgren PO, Hummel RP, Fischer JE. Effect of sepsis and starvation on amino acid uptake in skeletal muscle. J Surg Res 1987; 42:377-382.
  • Warner BW, James JH, Hasselgren PO, LaFrance R, Fischer JE. Effect of catabolic hormone infusion on organ amino acid uptake. J Surg Res 1987; 42:418-424.
  • Hasselgren PO, Chen IW, James JH, Sperling M, Fischer JE. Studies on the possible role of thyroid hormone in accelerated muscle protein breakdown during sepsis. Ann Surg 1987; 206:18-24.
  • Adlerberth A, Jagenburg R, Lindstedt G, Stenstrom G, Hasselgren PO: Urinary 3 methyl-histidine excretion and plasma amino acids in hyperthyroid patients preoperatively treated with antithyroid drug or β blocking agent. Metabolism 1987; 36:637-642.
  • Warner BW, Hasselgren PO, James JH, Bialkowska H, Rigel DF, Ogle C, Fischer JE. Superoxide dismutase in rats with sepsis: effect on survival rate and amino acid transport. Arch Surg 1987; 122:1142-1146.
  • Schroder T, Hasselgren PO, Joffe SN. Techniques of liver resection: comparison of suction knife, ultrasonic dissector, and contact neodymium YAG laser. Arch Surg 1987; 122:1166-1171.
  • Hummel RP, Warner BW, Pedersen P, Hasselgren PO, James JH, Ogle C, Fischer JE. In vitro effects of TNF, IL 1α and other monokines on skeletal muscle amino acid uptake and protein degradation. Surg Forum 1987; 38:13-15.
  • Hasselgren PO. Review: prevention and treatment in liver ischemia. Surg Gynecol Obstet 1987; 164:187-196.
  • Bengmark S, Hasselgren PO. Septic problems in liver surgery. Chir Gastroenterol 1987; 3:105-109.
  • Hasselgren PO, Fischer JE. Prevention of radiation enteritis. Special Comment. In: Nelson RL, Nyhus LM, eds. Surgery of the Small Intestine. Norwalk, CT: Appleton & Lange, 1987:217 219.
  • Hasselgren PO, Fischer JE. Nutritional support in sepsis. In: Lang CE, ed. Nutritional Support in Critical Care. Rockville, MD: Aspen Publishers, Inc., 1987:354-361.
  • Hummel RP, James JH, Warner BW, Hasselgren PO, Fischer JE. Evidence that cathepsin B contributes to skeletal muscle protein breakdown during sepsis. Arch Surg 1988; 123:221-224.
  • Sax HC, Talamini MA, Hasselgren PO, Rosenblum L, Ogle CK, Fischer JE. Increased synthesis of secreted hepatic proteins during abdominal sepsis. J Surg Res 1988; 44:109-116.
  • Hasselgren PO, Warner BW, Hummel RP, James JH, Ogle C, Fischer JE. Further evidence that accelerated muscle protein breakdown during sepsis is not mediated by prostaglandin E2. Ann Surg 1988; 207:399-403.
  • Hasselgren PO, James JH, Warner BW, Hummel RP III, Fischer JE. Protein synthesis and degradation in skeletal muscle from septic rats: response to leucine and α ketoisocaproic acid. Arch Surg 1988; 123:640-644.
  • Hasselgren PO, LaFrance R, Pedersen P, James JH, Fischer JE. Infusion of a branched chain amino acid enriched solution and α-ketoisocaproic acid in septic rats: effects on nitrogen balance and skeletal muscle protein turnover. JPEN 1988; 12:244-249.
  • Hummel RP, Warner BW, James JH, Hasselgren PO, Fischer JE. Effects of indomethacin and leupeptin on muscle cathepsin B activity and protein degradation during sepsis. J Surg Res 1988; 45:140-144.
  • Sax HC, Hasselgren PO, Talamini MA, Edwards LL, Fischer JE. Amino acid uptake in isolated, perfused liver: effect of trauma and sepsis. J Surg Res 1988; 45:50-55.
  • Pedersen P, Hasselgren PO, Li S, Hiyama DT, Fischer JE. Synthesis of acute phase proteins in perfused liver following administration of recombinant interleukin 1α to normal or adrenalectomized rats. J Surg Res 1988; 45:333-341.
  • Nordström G, Säljö A, Hasselgren PO. Studies on the possible role of oxygen derived free radicals for impairment of protein and energy metabolism in liver ischemia. Circ Shock 1988; 26:115-126.
  • Pedersen P, Li S, Hasselgren PO, LaFrance R, Fischer JE. Administration of balanced or BCAA-enriched amino acid solution in septic rats: effects on protein synthesis in liver. Ann Surg 1988; 208:714-720.
  • Adlerberth A, Persson S, Hansson G, Hasselgren PO. Protein synthesis and quantitative morphology in thyroid tissue from hyperthyroid patients after preoperative treatment with antithyroid or β adrenergic antagonist drugs. J Clin Endocrinol Metab 1988; 67:663-668.
  • Hummel RP, Hasselgren PO, James JH, Warner BW, Fischer JE. The effect of sepsis in rats on skeletal muscle protein synthesis in vivo and in periphery and central core of incubated muscle preparations in vitro. Metabolism 1988; 37:1120-1127.
  • Benson D, Hasselgren PO, James JH, Nelson JL, Fischer JE. Inhibition by insulin of myofibrillar protein breakdown in septic skeletal muscle. Surg Forum 1988; 39:36-37.
  • Hasselgren PO, Pedersen P, Sax HC, Warner BW, Fischer JE. Current concepts of protein turnover and amino acid transport in liver and skeletal muscle during sepsis. Arch Surg 1988; 123:992-999.
  • Hasselgren PO, Pedersen P, Sax HC, Warner BW, Fischer JE. Current research review: methods for studying protein synthesis and degradation in liver and skeletal muscle. J Surg Res.1988; 45: 389-415.
  • Pedersen P, Warner BW, Bjornson HS, Hiyama DT, Li S, Rigel DF, Hasselgren PO, Fischer JE. Hemodynamic and metabolic alterations during experimental sepsis in young and adult rats. Surg Gynecol Obstet 1989; 168:148-156.
  • Andersson R, Alwmark A, Hasselgren PO, Bengmark S. Management of liver trauma: a nonoperative approach in selected cases. Surg Res Comm 1989; 4:293-297.
  • Hasselgren PO, James JH, Benson DW, Hall Angerås M, Angerås U, Hiyama DT, Li S, Fischer JE. Total and myofibrillar protein breakdown in different types of rat skeletal muscle: effects of sepsis and regulation by insulin. Metabolism 1989; 38:634-640.
  • Benson D, Hasselgren PO, Hiyama D, James JH, Li S, Rigel D, Fischer JE. Effect of sepsis on calcium uptake and content in skeletal muscle and regulation in vitro by calcium of protein breakdown in control and septic muscle. Surgery 1989; 106:87-93.
  • Andersson R, Hasselgren PO, Bengmark S. Transfer of patients or surgeons in the management of major liver injury. Surg Res Comm 1989; 5:269-274.
  • Warner BW, Hummel RP, Hasselgren PO, James JH, Fischer JE. Inhibited amino acid uptake in skeletal muscle during fasting. JPEN 1989; 13:344-348.
  • Angerås U, Hall Angerås M, Hasselgren PO, Fischer JE. Elevated temperature in vitro stimulates total and myofibrillar protein breakdown in muscle from septic rats. Surg Forum 1989; 40:30-31.
  • Hall Angerås M, Angerås U, Hasselgren PO, Fischer JE. Myofibrillar protease activity and protein breakdown in skeletal muscle from septic rats. Surg Forum 1989; 40:111-113.
  • Pedersen P, Hasselgren PO, Warner BW, LaFrance R, Li S, Fischer JE. Protein synthesis in liver following infusion of the catabolic hormones corticosterone, epinephrine and glucagon in rats. Metabolism 1989; 38:927-932.
1970s
  • Frizell M, Hasselgren PO, Sjostrand J. Axoplasmic transport of acetylcholinesterase and choline acetyltransferase in the vagus and hypoglossal nerve of the rabbit. Exp Brain Res 1970; 10:526-531.
  • Sjostrand J, Frizell M, Hasselgren PO. Effects of colchicine on axonal transport in peripheral nerves. J Neurochem 1970; 17:1563-1570.
  • Hasselgren PO, Rottier A. Aneurysm of the pancreaticoduodenal artery. A case report. Acta Chir Scand 1976; 142:543-544.
  • Hasselgren PO, Bolin T. Postmenopausal tuberculous pyometra. A case report. Acta Obst Gyn Scand 1977; 56:23-25.
  • Hasselgren PO, Engquist S, Sundstrom C. Pneumatosis cystoides intestinalis. A case report. Ann Chir Gynecol 1977; 66:98-101.
  • Hasselgren PO, Almersjo O, Gustavsson B, Seeman T. Liver circulation and oxygen metabolism during short term ligation of the hepatic artery in the dog. Acta Chir Scand 1979; 145:471-477.
  • Hasselgren PO, Almersjo O, Gustavsson B, Seeman T. Amino acid incorporation into liver proteins during short term ligation of the hepatic artery in the dog. Eur Surg Res 1979; 11:366-380.
  • Hasselgren PO, Almersjo O, Gustavsson B, Seeman T. Amino acid incorporation into liver proteins during hemorrhagic shock in the dog. Eur Surg Res 1979; 11:267-276.
  • Almskog B, Hasselgren PO, Nylof U, Nordström G, Seeman T. Circulatory changes following multiple wounds to soft tissue. Acta Chir Scand (suppl) 1979; 489:261-270.
  • Gustavsson B, Baldesten A, Hasselgren PO, Almersjo O. A new assay of 5 FU in serum by isotachophoresis. J Chromatography 1979; 179:151-159.
  • Hasselgren PO. Circulatory and metabolic changes in liver ischemia. Hepatic blood flow and in vitro liver protein synthesis during occlusion of the hepatic artery and hemorrhagic shock. Studies in dogs and patients. Thesis, University of Göteborg, Sweden, 1979.